Role of Kidney
The Role of the Kidney in Glucose Homeostasis
After participating in this educational activity, participants should be better able to:
- Increase awareness of renal mechanism in glucose regulation
- Detail and clarify the multiple dimensions involved in glucose control in type 2 diabetes (T2DM)
- Develop a treatment plan that promotes adherence and incorporates renal glucose excretion into an overall management plan for patients with T2DM
The kidney has a key role in regulating glucose levels — by mediating the reabsorption of glucose back into the plasma — following filtration of the blood such that no glucose is lost. The sodium-glucose co-transporter 2 (SGLT2), a high capacity, low affinity transporter, is found mainly in the S1 segment of the proximal tubule and is responsible for approximately 90% of reabsorbed glucose by the kidney. Under normal circumstances, in individuals without type 2 diabetes (T2DM), the renal glomeruli filter approximately 180 g of glucose per day, virtually all of which is reabsorbed by the proximal tubules via an insulin independent process. In the context of T2DM, this process contributes to sustained elevated serum glucose levels, as patients with T2DM have an increased capacity for renal glucose reabsorption. Recent clinical data suggest that SGLT2 inhibitors reduce hyperglycemia by increasing urinary excretion of glucose. With new advances in the understanding and treatment of T2DM, there is an increased need for healthcare professionals to understand the existing clinical data on this topic, and this CME program will address the rational use of SGLT2 inhibitors in patients with T2DM.
This activity has expired and is no longer available for CME; however, we hope you still enjoy the education.